中国组织工程研究

中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (7): 1077-1081.doi: 10.3969/j.issn.2095-4344.2015.07.017

• 组织构建综述 tissue construction review • 上一篇    下一篇

骨代谢过程中雌激素的影响与作用

李洪亮，司家文，沈国芳   

  1. 上海市交通大学医学院附属第九人民医院口腔颅颌面科；上海市口腔医学重点实验室，上海市 200011
  • 出版日期:2015-02-12 发布日期:2015-02-12
  • 通讯作者: 沈国芳，博士，主任医师，上海市交通大学医学院附属第九人民医院口腔颅颌面科，上海市口腔医学重点实验室，上海市 200011
  • 作者简介:李洪亮，男，1989年生，吉林省延吉市人，汉族，在读硕士，主要从事颅颌面畸形的基础与临床研究。
  • 基金资助:

    国家自然科学基金面上项目(81371122)资助

Role of estrogen in bone metabolism

Li Hong-liang, Si Jia-wen, Shen Guo-fang   

  1. Department of Oral and Craniomaxillofacial Science, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
  • Online:2015-02-12 Published:2015-02-12
  • Contact: Shen Guo-fang, M.D., Chief physician, Department of Oral and Craniomaxillofacial Science, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
  • About author:Li Hong-liang, Studying for master’s degree, Department of Oral and Craniomaxillofacial Science, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81371122

PDF

668

被引次数

25

摘要：

背景：绝经后女性出现的骨质疏松是一种全身性的骨代谢障碍疾病，与雌激素水平的下降密切相关。

 

目的：分别从雌激素对破骨细胞和成骨细胞的作用综述了雌激素对骨代谢的影响。

 

方法：由第一作者使用计算机检索Medline 数据库，全国期刊全文数据库(CNKI)，检索词为“estrogen，osteoporosis，bone metabolism，osteoblasts，osteoclasts，osteogenesis，bone resorption”和“雌激素，骨质疏松症，骨代谢，成骨细胞，破骨细胞，骨生成，骨吸收”。从雌激素对破骨细胞、成骨细胞影响两个方面进行总结。共检索到 216篇文章，按纳入和排除标准对文献进行筛选，共纳入48篇文章。

 

结果与结论：雌激素水平下降破坏了体内成骨与破骨之间的动态平衡，从而导致骨质的吸收，骨量的减少、脆性增加、增加了骨折的风险。雌激素对成骨细胞、破骨细胞均产生调节作用，进而促进骨形成、抑制骨吸收，维持骨代谢平衡。

 


中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

关键词: 组织构建, 骨组织工程, 雌激素, 骨代谢, 成骨细胞, 破骨细胞, 骨改建, 国家自然科学基金

Abstract:

BACKGROUND: Postmenopausal osteoporosis is a systemic bone metabolic disorder that is closely associated with a decrease in the level of estrogen.

 
OBJECTIVE: To review the influence of estrogen on bone metabolism by exploring the role of estrogen in osteoblasts and osteoclasts.
METHODS: A computer-based retrieval of Medline database and CNKI was performed by the first author to search relevant articles addressing the role of estrogen on osteoblasts and osteoclasts using the keywords of “estrogen, osteoporosis, bone metabolism, osteoblasts, osteoclasts, osteogenesis, bone resorption” both in English and Chinese. Totally 216 articles were retrieved, and according to inclusion criteria, and 48 articles were finally retained.
RESULTS AND CONCLUSION: Estrogen deficiency is associated with a gap between bone resorption and formation, characterized by the loss of bone mass and strength that leads to fragility fractures. Estrogen can regulate the levels of osteoblasts and osteoclasts, thereby inhibiting bone resorption, increasing bone formation, and maintaining bone metabolism.


中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

Key words: Estrogen, Bone Metabolism, Osteoblasts, Osteoclasts

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